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OpenRouter Response API standardizes the tool calling interface across models and providers, making it easy to integrate external tools with any supported model.

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Prerequisites

Set OPENROUTER_API_KEY environment variable. 
from agno.agent import Agent
from agno.models.openrouter import OpenRouterResponses
from agno.tools.duckduckgo import DuckDuckGoTools

# ---------------------------------------------------------------------------
# Create Agent
# ---------------------------------------------------------------------------

agent = Agent(
    model=OpenRouterResponses(id="openai/gpt-oss-20b", reasoning={"enabled": True}),
    tools=[DuckDuckGoTools()],
    markdown=True,
)

agent.print_response("What is the latest news about AI?", stream=True)

# ---------------------------------------------------------------------------
# Run Agent
# ---------------------------------------------------------------------------

if __name__ == "__main__":
    pass

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Run the Example

# Clone and setup repo
git clone https://github.com/agno-agi/agno.git
cd agno/cookbook/90_models/openrouter/responses

# Create and activate virtual environment
./scripts/demo_setup.sh
source .venvs/demo/bin/activate

# Export relevant API keys
export OPENROUTER_API_KEY="***"

python tool_use.py